In the United States, hemp is often confused with marijuana. It’s a consumer misconception that has, for decades, slowed the market potential for hemp in the food, dietary supplement, textile, and even lumber industries. The dietary supplement industry, in particular, has a lot to gain from hemp, and not just with hemp oil and hemp protein. A substance called cannabidiol (CBD) has shown nutritional potential for years, yet the taboo around Cannabis has kept CBD off the radar. Now, with hemp gaining a better reputation, it looks as though its little compound is finally poised for big market growth. And much of that growth could be in stress and anxiety formulas.

What Is CBD?

CBD is a phytocannabinoid that is found in industrial hemp and marijuana, which are two different varieties of the Cannabis sativa plant. The current market for CBD as a dietary supplement is based on industrial hemp, not marijuana, because marijuana also contains significant amounts of tetrahydrocannabinol (THC), a phytocannabinoid that is psychoactive and, thus, capable of making a person high. Industrial hemp contains only negligible amounts of THC—no more than, say, poppy seeds contain opiates—and so it will not get you high. The plant is, thus, safe for human consumption and useful for components including CBD.

While CBD is not psychoactive like THC, it can still have a profound influence on the human brain, but first—is CBD legal?

Legal Status of CBD

In order to understand if CBD is legal for sale and consumption, one must look at the legality of hemp oil, which can be tailor-made for high concentrations of CBD.

Hemp oil is listed on the U.S. Harmonized Tariff Schedule (with no restrictions on CBD content) meaning that hemp oil is a legal U.S. import. This is important because federal law prohibits the farming of hemp in the United States. Hemp can only be purchased as an import. Some state laws override this federal law, but most of these, for now, just legalize hemp farming. At the time of this writing, Colorado and Kentucky are the only states that have laws permitting the farming and sale of hemp, and these are both very recent laws. The market for U.S.-grown hemp, thus, relies almost entirely on legal imports from established markets. Canada, Europe, and China are some of the world’s biggest hemp producers, so they control the U.S. market supply and will for at least a while longer.

As long as CBD-rich oils are imported, or farmed in states where cultivation and production is permitted by state law, CBD-rich hemp oils are legal. But they are not legal if their THC content is above 0.3%.1 This threshold keeps the distinction between hemp and marijuana in place.

Scientific Studies on CBD

As for how CBD works, CBD and other phytocannabinoids influence the brain by interacting with the brain’s very own cannabinoids, called endocannabinoids.

“Generally, phytocannabinoids like CBD can help to restore a more balanced ‘tone’ within the endocannabinoid system,” says Stuart Tomc, vice president of human nutrition for CBD oil supplier CannaVest Corp. (San Diego). “As such, CBD may positively, broadly affect various processes that control brain signaling, via neurotransmitter function, ion channel and membrane dynamics, inflammatory responses, and even gene expression.” It’s worth noting that Cannabis compounds aren’t the only ones capable of interacting with the brain’s endocannabinoid system. Compounds from flax and Brassica species, for instance, have shown potential to interact with the endocannabinoid system, too.2–3 With that said, why is this brain system so important?

The endocannabinoid system has broad influence over areas of the brain involved in sensations such as pain perception, movement, emotion, cognition, and sleep. For this reason, the endocannabinoid system likely has big sway over some brain health conditions. A blockage of cannabinoid receptors called CB1 receptors has been linked to behavioral effects consistent with antidepressant activity.4 Enhancement of anandamide, the first discovered endocannabinoid, may relieve chronic pain associated with neuropsychiatric disorders.5 Post-traumatic stress disorder appears to involve cannabinoid pathways, too.6

For all of the ways the endocannabinoid system can influence brain health, CBD’s own interaction with the endocannabinoid system could translate into some very significant health effects, and previously published studies so far offer positive indications. For extensive reading, a 2012 review of CBD studies provides a thorough overview of most of the existing human clinical trials (34 in total) on CBD for healthy and/or clinical patients.7 Here are some of the trials that stand out.


To explore the impact of an ingredient on anxiety, scientists often first look at that ingredient’s impact on cortisol levels in the human blood after ingestion. Cortisol levels are heightened when animals are under extreme duress, and when Brazilian researchers investigated the effect of CBD doses on human cortisol levels in 11 volunteers in 1993, they found that CBD decreased cortisol levels significantly more than placebo. CBD subjects also reported a sedative effect from the treatment.8

Also in 1993, the same researchers compared the effects of CBD and two anxiety medications, ipsapirone and diazepam, on a group of 40 healthy individuals assigned to a simulated public speaking test. Using a Visual Analogue Mood Scale (VAMS) to assess personal anxiety before and after the public speaking test, the researchers determined that diazepam lowered anxiety before and after the test, while the ipsapirone and CBD only lowered anxiety after the test.9 Years later, in 2004, another team of Brazilian researchers analyzed CBD, but they upped the dosage by 100 mg (now 400 mg of CBD). Compared to placebo, subjects in this study reported significantly decreased anxiety and increased mental sedation. Brain imaging tests suggested that such effects were mediated in specific regions of the brain.10

Aside from a potential influence on healthy volunteers, CBD has shown some promise in subjects with established social anxiety disorders. Two studies in 2011 yielded favorable results for CBD supplementation in this type of population. In the first study, CBD use was associated with decreases in subjective anxiety and was accompanied by (presumably significant) changes in regional cerebral blood flow.11 The second study tied CBD to reduced anxiety and discomfort in response to a simulated public speaking test.12

Curiously, the presence of CBD alongside THC, in marijuana, has even shown potential to alleviate THC-induced anxiety and psychosis.